Clinical Pharmacology of Cerebral Ischemia

A distinguished international panel of authors define our current unde rstanding of neuronal damage after ischemia and critically review the significant recent developments and progress in cerebrovascular accide nt (CVA) drug trials, both in animal models and in the clinical settin g. These leading basic and fundamental authorities survey such importa nt new drugs as calcium-influx inhibitors, free-radical scavenging dru gs, glutamate and glycinergic antagonists, and immune suppressors. The y also evaluate all the latest findings concerning calcium homeostasis , glutamate toxicity, gene activation, and the role of free radicals, glycine, and hormones. Chapters devoted to the neuroimaging of stroke, clinical trials, and the role of cerebral immune activation complete this informative collection of cutting-edge reviews.