Multiple Organ Failure: Pathophysiology, Prevention, and Therapy

This text brings together international experts to explore the pathoph ysiology, prevention, and treatment of Systemic Inflammatory Response Syndrome, Multiple Organ Dysfunction Syndrome and Multiple Organ Failu re with an emphasis on injury, inflammation, ischemia, and inflammatio n. Emphasizing material of clinical relevance to patient care, 75 chap ters address development of SIRS, MODS and MOF including risk factors and history; mechanisms of SIRS and organ failure; mediators and effec tors including cytokines, biologic control of inflammation, histamine, nitric oxide; prevention and general therapy including intensive care monitoring, surgical intervention and operating for trauma; specific remote organ failure including lungs, stomach, kidneys, liver and CNS; and a comprehensive summary of therapeutic horizons. Generously illus trated with over 300 drawings, photographs and tables, this volume is an invaluable resource.