Rational Drug Design

Drug research and discovery are of critical importance in human health care. Computational approaches for drug lead discovery and optimizati on have proven successful in many recent research programs. These meth ods have grown in their effectiveness not only because of improved und erstanding of the basic science - the biological events and molecular interactions that define a target for therapeutic intervention - but a lso because of advances in algorithms, representations, and mathematic al procedures for studying such processes. This volume surveys some of those advances. A broad landscape of high-profile topics in computer- assisted molecular design (CAMD) directed to drug design are included.