Primary Aldosteronism: Molecular Genetics, Endocrinology, and Translational Medicine

Primary Aldosteronism (PA) is a disease caused by the overproduction of aldosterone hormone from the adrenal glands. PA causeshypertensionand the majority with this diseaseare undiagnosed for PA.There are new insights into this matter by using biochemistry as well as advanced radiology. In 2011, a breakthrough in the genetic derangements came, identifying a mutated potassium channel gene – KCNJ5 – in about 40% of PA with adenoma. Chapters in this bookinclude a history of the disorder, epidemiology, genetics derangements, the KCNJ5 mutations and phenotype and more.