Intracellular Pathogens I: Chlamydiales

How these obligately intracellular bacteria use eukaryotic cells to cause disease

Diseases caused by Chlamydia are a major public health challenge. Each year, more cases of chlamydial infection are reported to the Centers for Disease Control, now outnumbering all other infectious' diseases combined.

This detailed exploration of intracellular infection has multiple chapters examining how chlamydiae bind to and enter the host cell, establish an intracellular niche in the membrane-bound chlamydial inclusion regulate their own gene expression during the unusual developmental cycle, and exploit the host cell to support the infection.

Intracellular Pathogens I: Chlamydiales

Describes findings from newly available genome sequences of multiple chlamydial species and strains

Explores the host immune response, including its role in pathogenesis and progress toward a chlamydial vaccine

Discusses how biomamematical modeling is being used to provide insight into chlamydial infection arid disease

Features recent developments in experimental genetics that enable exciting new approaches to genetically manipulate chlamydiae