Chromosomes and Genes in Acute Lymphoblastic Leukemia

This monograph, written by one of the world's leading cytogeneticists in the field of hematology, decribes the large number of chromosome changes that have now been implicated in acute lymphoblastic leukemia (ALL). Both the well established method of banding and the newer fluorescence in-situ hybridisation, Southern blotting and polymerase chain reaction techniques are reviewed. A glossary of terms used in this field, essential for all non-chromosomal cogniscenti, is included. The most important translocations, partial deletions and chromosome gains and losses are illustrated and the clinical and molecular significance of each is described.