Modeling and Analysis of Signal Transduction Networks

Biological pathways, such as signaling networks, are a key component of biological systems

of each living cell. In fact, malfunctions of signaling pathways are linked to a number of

diseases, and components of signaling pathways are used as potential drug targets. Elucidating

the dynamic behavior of the components of pathways, and their interactions, is one of the key

research areas of systems biology.

Biological signaling networks are characterized by a large number of components and an

even larger number of parameters describing the network. Furthermore, investigations of

signaling networks are characterized by large uncertainties of the network as well as limited

availability of data due to expensive and time-consuming experiments. As such, techniques

derived from systems analysis, e.g., sensitivity analysis, experimental design, and parameter

estimation, are important tools for elucidating the mechanisms involved in signaling networks.

This Special Issue contains papers that investigate a variety of different signaling networks via

established, as well as newly developed modeling and analysis techniques.