Slow Synaptic Responses and Modulation

The flow of information coded as impulses through neuronal circuits is regulated not only by fast impulse-to-impulse synaptic transmission b ut also by slow synaptic transmission and modulation. The concept of s low synaptic responses and modulation emerged from studies on sympathe tic ganglia, then was expanded to elucidate the detailed mechanisms in peripheral and central synapses. These key developments, along with r ecent progress in the field, are presented in this book. Major topics include the structure and function of single ion channels, neurotransm itter exocytosis, intracellular Ca2+ dynamics, plasticity, and gene ex pression. Each chapter opens with an explanatory review, followed by d escriptions of recent findings in this rapidly evolving field. The boo k is thus a valuable resource for researchers working in the neuroscie nces, physiology, and pharmacology, from introductory to advanced leve ls.