Hand-Sch Ller-Christian Disease

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Hand-Schüller-Christian disease is associated with multifocal Langerhans cell histiocytosis. It is associated with a triad of exophthalmos, lytic bone lesions (often in the skull), and diabetes insipidus (from pituitary stalk infiltration). It is named for Alfred Hand, Artur Schüller, and Henry Asbury Christian. Langerhans cell Histiocytosis (LCH) is a rare disease involving clonal proliferation of Langerhans cells, abnormal cells deriving from bone marrow and capable of migrating from skin to lymph nodes. Clinically, its manifestations range from isolated bone lesions to multisystem disease.