Neurodegeneration in Multiple Sclerosis

Basic understanding of neurodegeneration and its mechanisms: Neurobiology.- Neuropathology. Neurophysiology.- Assessing neurodegeneration, MRI aspects I: Atrophy measurements.- T1 black holes and grey matter damage.-MT MRI.- Assessing neurodegeneration, MRI aspects II: DW MRI.-MR spectroscopy.-Functional MRI and adaptive plasticity.- Evaluation of MRI outcomes: Validation of MRI surrogates.- Defining responders/non responders: clinical aspects.-Defining responders/non responders: statistical aspects.-Analysis of covariance.-The issue of multiple comparisons.-Lessons from neurodegenerative diseases: Alzheimer's disease.-Other neurodegenerative conditions.-Incorporation of other biomarkers.-Toward a consensus agreement: Critical review of existing trials.-How to design the next MS trial of neurodegeneration: clinical aspects.-How to design the next MS trial of neurodegeneration: MRI aspects.