Structural Aspects of Protein Synthesis

This highly illustrated book provides an up-to-date description of the structure and function of the translation system including ribosomes, tRNAs, translation factors, antibiotics and aminoacyl-tRNA synthetases.

Research on translation is undergoing rapid changes and is receiving significant attention as evidenced by the Nobel Prize in Chemistry 2009. The structural research by crystallography and cryo-EM forms part of an interactive framework that involves biochemistry and molecular computation. The book provides a comprehensive overview of translation in light of the structural results. It is a valuable resource for scientists in this and related fields, as well as for students taking courses with a focus on translation.

There is no other book in this field currently except the previous edition of this book. The authors have for a long time worked in the field of structure and function of the translation system.

Contents:

• The Basics of Translation
• Historical Milestones
• Methods of Studying Structure
• The Message — mRNA
• The Adaptor — tRNA
• The Workbench — Ribosomes
• The Structure of the Ribosome
• Ribosomal Sites and Ribosomal States
• The Catalysts — Translation Factors
• Inhibitors of Protein Synthesis — Antibiotics, Resistance
• The Process — Translation
• Protein Processing, Folding and Targeting
• Evolution of the Translation Apparatus

Readership: Upper level undergraduates and graduate students with an interest in protein synthesis; researchers in cell and molecular biology, biochemistry and biophysics who need to get an overview of translation.