Cellular Therapy Of Cancer: Development Of Gene Therapy Based Approaches: Development of Gene Therapy Based Approaches

Cancer research has progressed enormously in recent years. This review volume will address recent findings in the area of T-cell therapy for cancer, including use of tumour infiltrating lymphocytes (TILs) as a therapy for melanoma, choice of target antigens, advances in engineered receptors, methods of gene transfer to T cells, review of cell processing methods and clinical trial design. Written by leadings scientists in the field, this up-to-date review on cancer research will be an important reference source to the researchers and healthcare professionals in the field.

• Challenges of T-Cell Therapy (Naomi Taylor, Anna Mondino and Balbino Alarcon)
• Gene Transfer into T Cells (David Gilham and Hinrich Abken)
• TCR-Engineered T Cells (Reno Debets and Ton Schumacher)
• T-Bodies: Antibody-Based Engineered T-Cell Receptors (John Bridgeman, Andreas A Hombach, David Gilham, Zelig Eshhar and Hinrich Abken)
• T-Cell Engineering and Expansion — GMP Issues (Cor Lamers and Ryan Guest)
• Clinical Trial Design (Robert Hawkins, John Haanen and Fiona Thistlethwaite)